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Peptide record

TPDB61572

Pep1 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB61572
Pep1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanoparticles
Sequence
CRRRWHHHHHWRRRC
Physicochemical Analysis
C94H139N45O16S2
ANDEQGILKMFPSTYV
R
2219.55
12.40
11
0
2
+6
5.48
-2.653
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11125
501.23
2
Residue Composition
number
0
A
6
R
0
N
0
D
2
C
0
E
0
Q
0
G
5
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 5 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
15
C94H139N45O16S2
2219.55
12.40
+6
5.48
-2.653
Free
Nanoparticles
L
Cationic
Linear
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
pEGFP-N1
In both cell lines at N:P 12, Pep1-4 indicated successful transfection.
In vitro
CCCCCSSCGGGTCCCC
Additional Detail Fields 1 fields
CCCCCSSCGGGTCCCC