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Peptide record

TPDB61568

Int PMA-R9 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61568
Int PMA-R9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRRRRRRRRRRPLGLAGNGR
Physicochemical Analysis
C99H188N54O22S1
DEQHIKMFSTWYV
R
2518.99
13.05
11
0
3
+11
8.28
-2.195
44.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
1
A
11
R
1
N
0
D
1
C
0
E
0
Q
3
G
0
H
0
I
2
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 11 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
20
C99H188N54O22S1
2518.99
13.05
+11
8.28
-2.195
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht-1080 (Human Fibrosarcoma) Cells

Assay & Model

HT-1080 tumor bearing Female BALB/c nude mice (22−24 g)
HT-1080 tumor bearing Female BALB/c nude mice (22−24 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Doxorubicin loaded liposome
Mitochondria, Endoplasmic Reticulum and Golgi Apparatus
Cellular internalization of Int PMA-R9-Lip-DOX significantly increased relative to cLip-DOX and R9-Lip-DOX
Clathrin-independent and caveolin-independent endocytic pathways
In vitro and in vivo
CCCCCCCCSCCCCCSSSTTC
Additional Detail Fields 1 fields
CCCCCCCCSCCCCCSSSTTC