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Peptide record

TPDB61564

branched-mR9(B-mR9) mR9 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB61564
branched-mR9(B-mR9) mR9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRRRRRRRRRCRRRRRRRRRC
Physicochemical Analysis
C117H233N75O22S3
ANDEQGHILKMFPSTWYV
R
3138.81
12.94
18
0
0
+18
13.86
-3.500
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
3.98
3
Residue Composition
number
0
A
18
R
0
N
0
D
3
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 18 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C117H233N75O22S3
3138.81
12.94
+18
13.86
-3.500
Free
L
Cationic
Linear Branched
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hek 293, HeLa, Skov3, And Nci-H460 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
pDNA(GFP)
Cytoplasm
B-mR9/pDNA polyplex had high transfection efficiency compared to the conventional linear R9 and mR9 CPP.
In vitro
CCSSGGGGGSSGGGGGGCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Hek 293, HeLa, Skov3, And Nci-H460 Cells

Assay & Model

Female BALB/c nude mice (5-week-old)
Female BALB/c nude mice (5-week-old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Branched L Cationic
Synthetic
pDNA(GFP) and VEGF siRNA (siVEGF)
Cytoplasm and nucleus
B-mR9/pDNA polyplex had high transfection efficiency compared to the conventional linear R9 and mR9 CPP.
Macropinocytosis and caveolae mediated endocytosis
In vitro and in vivo
CCSSGGGGGSSGGGGGGCCCC
Additional Detail Fields 1 fields
CCSSGGGGGSSGGGGGGCCCC