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Peptide record

TPDB61563

cNGR-tiR9 Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB61563
cNGR-tiR9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRRRRRRRRRCNGRC
Physicochemical Analysis
C75H146N46O17S3
ADEQHILKMFPSTWYV
R
2060.46
12.58
10
0
0
+10
7.81
-2.760
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
6.07
4
Residue Composition
number
0
A
10
R
1
N
0
D
3
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 10 N: 1 D: 0 C: 3 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
15
C75H146N46O17S3
2060.46
12.58
+10
7.81
-2.760
Free
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht1080 (Human Fibrosarcoma) Cells

Assay & Model

Female BALB/c nude mice weighing 22–24 g
Female BALB/c nude mice weighing 22–24 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Dox-loaded nanoliposomes
Nucleus , Mitochondria, Endoplasmic Reticulum, And Golgi Apparatus And Cytosol
Cellular Dox fluorescence intensity for cNGR-tiR9-Lip-Dox was about 1.3-fold higher than that of cNGR-Lip-Dox
Lipid-raft-independent endocytosis
In vitro and in vivo
CCCCCC
Additional Detail Fields 1 fields
CCCCCC