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Peptide record

TPDB61561

R9 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB61561
R9
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, and Peptipedia, with an available 3D structural model.
Sequence
CRRRRRRRRR
Physicochemical Analysis
C57H115N37O11S1
ANDEQGHILKMFPSTWYV
R
1526.84
12.94
9
0
0
+9
7.05
-3.800
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
9
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C57H115N37O11S1
1526.84
12.94
+9
7.05
-3.800
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ht-1080 (Human Fibrosarcoma) Cells

Assay & Model

HT-1080 tumor bearing Female BALB/c nude mice (22−24 g)
HT-1080 tumor bearing Female BALB/c nude mice (22−24 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Doxorubicin loaded liposome
Mitochondria, Endoplasmic Reticulum and Golgi Apparatus
R9-Lip-DOX demonstrated 1.82-fold higher cellular fluorescence than cLip-DOX
Clathrin-independent and caveolin-independent endocytic pathways
In vitro and in vivo
CCCCCGGGSSSCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCGGGSSSCCCCCCCCC