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Peptide record

TPDB61560

R8-EGR Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61560
R8-EGR
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Addition of Cysteine
Sequence
CRRRRRRRREGR
Physicochemical Analysis
C64H125N39O15S1
ANDQHILKMFPSTWYV
R
1713.01
12.70
9
1
0
+8
9.08
-3.492
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
9
R
0
N
0
D
1
C
1
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C64H125N39O15S1
1713.01
12.70
+8
9.08
-3.492
Free
L
Cationic
Linear
Addition of Cysteine
N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C6 Cells, bEnd.3 Cells And HeLa Cells

Assay & Model

C6 glioma bearing Balb/c mice
C6 glioma bearing Balb/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
CFPE/ DiR-labeled Liposome and paclitaxel (PTX)
EGR-Lip increased the R8-modified liposomal uptake on C6 cells and bEnd.3 cells by 1.83-fold and 1.59-fold respectively
Receptor mediated endocytosis
In vitro and in vivo
CGGGGGGHHHHHC
Additional Detail Fields 1 fields
CGGGGGGHHHHHC