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Peptide record

TPDB61553

CRHC Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB61553
CRHC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Polyplexes
Sequence
CRRRRRHHHHHHHRRRRC
Physicochemical Analysis
C102H169N59O19S2
ANDEQGILKMFPSTWYV
R
2589.97
12.70
16
0
0
+10
13.53
-3.217
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
4.83
2
Residue Composition
number
0
A
9
R
0
N
0
D
2
C
0
E
0
Q
0
G
7
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 7 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
18
C102H169N59O19S2
2589.97
12.70
+10
13.53
-3.217
Free
Polyplexes
L
Cationic
Linear
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Dividing And Differentiated ARPE-19 And Differentiated Hfrpe Cells.

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
pFB-Gluc and pEGFP-C2 GAPDH siRNA
Nucleus
Experiments with Gaussia luciferase reporter gene clearly showed that cationic peptides achieved 10–100 fold greater transgene expression than amphipathic peptides in all studied cell types. CS coating of the peptide-based polyplexes improved transfection efficiency in both dividing ARPE-19 cells by 10 times and by five times in the corresponding differentiated cells
In vitro
CCSTTHHHHHHHHHCCHHHHHHTSSCSCC
Additional Detail Fields 1 fields
CCSTTHHHHHHHHHCCHHHHHHTSSCSCC