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Peptide record

TPDB61550

Cys-R4 Cell-penetrating Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB61550
Cys-R4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 5-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: CFPE-labeled liposomes N-terminal: Addition of Cysteine
Sequence
CRRRR
Physicochemical Analysis
C27H55N17O6S1
ANDEQGHILKMFPSTWYV
R
745.90
12.40
4
0
0
+4
3.00
-3.100
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
4
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C27H55N17O6S1
745.90
12.40
+4
3.00
-3.100
Free
CFPE-labeled liposomes
L
Cationic
Linear
Addition of Cysteine
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

C6 Cells

Assay & Model

C6 xenograft tumor bearing Balb/c mice
C6 xenograft tumor bearing Balb/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Lipososmes
Cytoplasm
Cellular uptake of R4-Lip didn’t show a significant difference compared to PEGylated liposomes.
In vitro and in vivo
CCSCC
Additional Detail Fields 1 fields
CCSCC