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Peptide record

TPDB61549

TAT-HA2 Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB61549
TAT-HA2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRRRQRRKKRGGDIMGEWGNEIFGAIAGFLG
Physicochemical Analysis
C152H248N54O40S2
HPSTYV
G
3536.10
11.76
8
3
10
+5
6.77
-0.810
56.77
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5500
155.54
3
Residue Composition
number
2
A
6
R
1
N
1
D
1
C
2
E
1
Q
7
G
0
H
3
I
1
L
2
K
1
M
2
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 6 N: 1 D: 1 C: 1 E: 2 Q: 1 G: 7 H: 0 I: 3 L: 1 K: 2 M: 1 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
31
C152H248N54O40S2
3536.10
11.76
+5
6.77
-0.810
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Jurkat Cells And Mouse Primary T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Fusogenic
AAV6-green fluorescent protein (AAV6-GFP)
TAT-HA2 at 0.2 mM resulted in a two-fold increase in transduction efficiency (from 17.9% to 34.6%, p < 0.05).
In vitro
CCCCCCCTTTSSCCSCC
Additional Detail Fields 1 fields
CCCCCCCTTTSSCCSCC