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Peptide record

TPDB61543

[Pen] Cys-penetratin Penetratin P16 Cell-penetrating Peptides standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB61543
[Pen] Cys-penetratin Penetratin P16
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 17-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD, CellPPD-MOD, CPPsite3.0, and other sources, with an available 3D structural model.
Sequence
CRQIKIWFQNRRMKWKK
Physicochemical Analysis
C107H173N35O21S2
ADEGHLPSTYV
K
2349.89
12.16
7
0
6
+7
2.05
-1.482
45.88
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11000
468.11
4
Residue Composition
number
0
A
3
R
1
N
0
D
1
C
0
E
2
Q
0
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
17
C107H173N35O21S2
2349.89
12.16
+7
2.05
-1.482
Free
L
Amphipathic
Linear Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O N[C@@H](Cc1ccccc1)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)NCC(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)NCC(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)NCC(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

PC-3

Source & Reference

CPPsite3.0
CPPsite3
US 20090186802

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Nucleic acid (siRNA)
In vitro
CCSCCCCSSTTCSCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Mouse xenograft model of BALB.Luc human non-Hodgkin lymphoma.
Mouse xenograft model of BALB.Luc human non-Hodgkin lymphoma.

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
THIOMAB™ antibody-drug conjugates, or TDCs
In vivo
CCSSCCCCTTSCCCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Hcec, ARPE-19 And HUVECs Cell Lines

Assay & Model

Male C57BL/6J mice and Male New Zealand rabbits (1.9–2.5 kg) for ex-vivo
Male C57BL/6J mice and Male New Zealand rabbits (1.9–2.5 kg) for ex-vivo

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Protein derived
BSA, FAM and Nile red labelled liposome (PenHA-Lip) loaded with Conbercept(Conb)
Cytoplasm
MFI of the PenHA-Lip/Nr group was 2.10-fold higher than that of Lip-Nr.
In-vitro, in-vivo and ex vivo
CCCCCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

CHO-K1, CHO-Pgsa745

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Cyclic L Amphipathic
Synthetic
Protein kinase C inhibitor (PKCi)
Cytoplasm
Moderate improve in cellular uptake of cyclic CPP
GAG-dependent endocytosis and Direct translocation
In vitro
Additional Detail Fields 1 fields
CCSCCCCSSTTCSCCCC CCSSCCCCTTSCCCC CCCCCCCC