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Peptide record

TPDB61539

iNGR Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB61539
iNGR
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0 MLCPP 2.0 Peptipedia TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from BBPpredict, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Sequence
CRNGRGPDC
Physicochemical Analysis
C35H60N16O13S2
AEQHILKMFSTWYV
RCG
977.08
8.30
2
1
0
+1
3.26
-1.489
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
12.79
3
Residue Composition
number
0
A
2
R
1
N
1
D
2
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 1 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
9
C35H60N16O13S2
977.08
8.30
+1
3.26
-1.489
Free
L
Linear
NGR, R/KXXR/K (CendR) CendR, NGR CendR motif (R/KXXR/K)
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 8 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs and 4T1

Assay & Model

Female BALB/c mice
Female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Small molecule drug (Doxorubicin) and Fluorophore (FAM)
In vitro and in vivo
CCSSCSSCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Targeting
Breast cancer, Ovarian cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Compositions for treating cancer and methods for making the same
2019
US 10300143 B2
US 10300143 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
4T1 breast cancer cell line, MDA-MB-468 breast cancer cell line, 4306-ovarian cancer cell line, Lewis lung carcinoma (LLC) cells, hepatocellular carcinoma cells (CP20)
BALB/c mice
Synthetic
diacylglycerols, dialkylglycerols
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, stomach cancer, Pancreatic cancer, Colorectal cancer, Ovarian cancer, Renal cell carcinoma, Prostate cancer, Brain tumor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Noxa-derived, cell death-inducing peptide eMTD
2022
US 11248024 B2
US 11248024 B2

Other

Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line
6-week-old BalB/C mice
Synthetic
necrosis-inducing peptide, Fluorescein (FAM)
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing
Lung cancer, Breast cancer, Liver cancer, Melanoma, Pancreatic cancer, Colorectal cancer, Prostate cancer

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell (HUVECs)
Targeting
4T1 Breast cancer
CD13, NRP-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
De novo design of a tumor-penetrating peptide
2012
Luca Alberici et al. Cancer Res. 2013 Jan 15 73(2):804-12.

Other

HUVECs, 4T1 cells,
female BALB/c mice at the age of 4–6 weeks
Synthetic
T7 phage/CX7C peptide library
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
VEGF, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-penetrating peptides
2013
Tambet Teesalu et al. Front Oncol. 2013 Aug 27:3:216.

Other

Phage Display library
doxorubicin
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Neuropilin-1, CD13

Source & Reference

TumorHoPe2.0
TumorHoPe2
Evaluation of (68)Ga-labeled iNGR peptide with tumor-penetrating motif for microPET imaging of CD13-positive tumor xenografts
2016
Mingxuan Zhao et al. Tumour Biol. 2016 Sep 37(9):12123-12131.

Other

CD13-positive HT-1080, CD13-negative HT-29 cell line
Synthetic
DOTA , 68Ga
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Tumor vessel, Tumor cell
Homing
Neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
iNGR-modified PEG-PLGA nanoparticles that recognize tumor vasculature and penetrate gliomas
2014
Kang T et al. Biomaterials.2014 May 35(14):4319-32

Other

Primary human umbilical vein endothelial cells (HUVEC cells), U87
Male Sprague Dawley (SD) rats, male BALB/c nude mice
Synthetic
Poly (ethylene glycol) (PEG)-poly (D,L-lactic-co-glycolic acid) (PLGA)
Additional Detail Fields 5 fields
diacylglycerols, dialkylglycerols necrosis-inducing peptide, Fluorescein (FAM) nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide] doxorubicin DOTA , 68Ga Poly (ethylene glycol) (PEG)-poly (D,L-lactic-co-glycolic acid) (PLGA)
CCSSCSSCC
4T1 breast cancer cell line, MDA-MB-468 breast cancer cell line, 4306-ovarian cancer cell line, Lewis lung carcinoma (LLC) cells, hepatocellular carcinoma cells (CP20) Sp2/0, CHO (Chinese hamster ovary) K1, CHO DG44, PER.C6, W138, BHK, COS7, 293, HepG2, Huh7, 3T3, RIN, MDCK cell line PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line HUVECs, 4T1 cells, CD13-positive HT-1080, CD13-negative HT-29 cell line Primary human umbilical vein endothelial cells (HUVEC cells), U87
BALB/c mice 6-week-old BalB/C mice BALB/c athymic nude mice female BALB/c mice at the age of 4–6 weeks Male Sprague Dawley (SD) rats, male BALB/c nude mice
T7 phage display library T7 phage/CX7C peptide library