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Peptide record

TPDB61528

RGD Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB61528
RGD
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, Peptipedia, and TumorHoPe2.0, with an available 3D structural model.
Sequence
CRGDC
Physicochemical Analysis
C18H32N8O8S2
ANEQHILKMFPSTWYV
C
552.62
5.95
1
1
0
-0
1.57
-0.680
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
22.62
2
Residue Composition
number
0
A
1
R
0
N
1
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C18H32N8O8S2
552.62
5.95
-0
1.57
-0.680
Free
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs and 4T1

Assay & Model

Female BALB/c mice
Female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Small molecule drug (Doxorubicin) and Fluorophore (FAM)
In vitro and in vivo
CCCCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
VEGF, neuropilin-1

Source & Reference

TumorHoPe2.0
TumorHoPe2
Tumor-penetrating peptides
2013
Tambet Teesalu et al. Front Oncol. 2013 Aug 27:3:216.

Other

Phage Display library
doxorubicin
Additional Detail Fields 5 fields
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide] doxorubicin
CCCCC
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
T7 phage display library