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Peptide record

TPDB61525

cyclic [CR]4 cyclic [CR]5 linear (CR)5 Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB61525
cyclic [CR]4 cyclic [CR]5 linear (CR)5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRCRCRCRCR
Physicochemical Analysis
C45H87N25O11S5
ANDEQGHILKMFPSTWYV
RC
1314.65
9.44
5
0
0
+5
2.85
-1.000
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
250
19.02
5
Residue Composition
number
0
A
5
R
0
N
0
D
5
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 5 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C45H87N25O11S5
1314.65
9.44
+5
2.85
-1.000
Free
L
Cationic
Linear Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 6 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
CF-labelled 3TC
l(CR)5 enhance cargo uptake by 10-fold,compared to that of CF-3TC alone in CCRF-CEM cells.
In vitro
CCCCCSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
CF-labelled 3TC
c[CR]4 showed highest cargo uptake by 16-fold, compared to that of CF-3TC alone in CCRF-CEM cells.
Fluid phase and clathrin-mediated endocytosis
In vitro
CCCSSSCSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
CF-labelled 3TC
c[CR]5 enhance cargo uptake by12-fold, compared to that of CF-3TC alone in CCRF-CEM cells.
In vitro
CCCSSSCSCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
CF-labelled GpYEEI
The cellular uptake of F0-GpYEEI in CCRF-CEM cells was improved by 17 -fold with l(CR)5 than phosphopeptide alone
In vitro
CCCCCSCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
CF-labelled GpYEEI
The cellular uptake of F0-GpYEEI in CCRF-CEM cells was improved by 20-fold with c[CR]4 than phosphopeptide alone
Fluid phase and clathrin-mediated endocytosis
In vitro
CCCSSSCSCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Cyclic L Cationic
Synthetic
CF-labelled GpYEEI
The cellular uptake of F0-GpYEEI in CCRF-CEM cells was improved by 18-fold with c[CR]5 than phosphopeptide alone
In vitro
CCCSSSCSCC
Additional Detail Fields 1 fields
CCCCCSCC CCCSSSCSCC