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Peptide record

TPDB61524

linear (CR)4 Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB61524
linear (CR)4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CRCRCRCR
Physicochemical Analysis
C36H70N20O9S4
ANDEQGHILKMFPSTWYV
RC
1055.32
9.38
4
0
0
+4
2.28
-1.000
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
250
23.69
4
Residue Composition
number
0
A
4
R
0
N
0
D
4
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 4 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
8
C36H70N20O9S4
1055.32
9.38
+4
2.28
-1.000
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
CF-labelled 3TC
l(CR)4 enhance cargo uptake by 6 fold, compared to that of CF-3TC alone in CCRF-CEM cells.
In vitro
CTTTTC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
CF-labelled GpYEEI
The cellular uptake of F0-GpYEEI in CCRF-CEM cells was improved by 4-fold with l(CR)4 than phosphopeptide alone.
In vitro
CTTTTC
Additional Detail Fields 1 fields
CTTTTC