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Peptide record

TPDB61522

cPF4PD_A488 Cell-penetrating Peptides standard
35 amino acids
Basic Information
3D PDB MODEL
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TPDB61522
cPF4PD_A488
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 35-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
CQAPLYKKIIKKLLESGGSGGAPLYKKIIKKLCES-NH2
Physicochemical Analysis
C174H298N44O46S2
RNDHMFTWV
K
3806.67
10.10
8
2
13
+6
7.13
-0.169
106.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
3105
81.57
8
Residue Composition
number
2
A
0
R
0
N
0
D
2
C
2
E
1
Q
4
G
0
H
4
I
5
L
8
K
0
M
0
F
2
P
3
S
0
T
0
W
2
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 2 E: 2 Q: 1 G: 4 H: 0 I: 4 L: 5 K: 8 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 2 V: 0
Chemical Descriptors
35
C174H298N44O46S2
3806.67
10.10
+6
7.13
-0.169
Amidation
L
Cationic
Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mm96L And Hacat Cells MCF7 And MDA-MB-231 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
A488 dye
Cytoplasm and also colocalized With Mitochondrial Membranes
Trend in internalization efficacy was similar for cPF4PD-A488 and cPF4Pext_pDI-A488 with MM96L ~ MDA-MB-231 > HaCaT > MCF7.
In vitro
CCCCHHHHHHHHHHHHSSTTSCHHHHTTTHHHHTC
Additional Detail Fields 1 fields
CCCCHHHHHHHHHHHHSSTTSCHHHHTTTHHHHTC