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Peptide record

TPDB61521

p4 (p4-TDN) Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB61521
p4 (p4-TDN)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: tetrahedral DNA (TDN) nanostructures
Sequence
CPVTRPPR
Physicochemical Analysis
C39H68N14O10S1
ANDEQGHILKMFSWY
P
925.12
10.90
2
0
1
+2
2.94
-0.975
36.25
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
2
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
3
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 3 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
8
C39H68N14O10S1
925.12
10.90
+2
2.94
-0.975
Free
tetrahedral DNA (TDN) nanostructures
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

U87Mg Cells And Hek293 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
doxorubicin (DOX)
Cytoplasm
dsDNA showed minimal fluorescence while the TDN and p-TDN structures showed time-dependent uptake,reaching to a balance at nearly 6h.
Endocytosis
In vitro
CCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCC