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Peptide record

TPDB61520

MCo-RM1 Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB61520
MCo-RM1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CPRILRRCRRDSDCPGACICKGNGYCGSGSDGGV
Physicochemical Analysis
C138H231N51O46S6
EQHMFTW
G
3533.03
8.31
6
3
6
+3
6.85
-0.479
45.88
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
52.79
11
Residue Composition
number
1
A
5
R
1
N
3
D
6
C
0
E
0
Q
7
G
0
H
2
I
1
L
1
K
0
M
0
F
2
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 3 C: 6 E: 0 Q: 0 G: 7 H: 0 I: 2 L: 1 K: 1 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
34
C138H231N51O46S6
3533.03
8.31
+3
6.85
-0.479
Free
L
Cyclic
Free
N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Alexa fluor® 488 at Lys
Cytoplasm
MCo-RM1 has a 22% improvement in internalization efficiency compared to its parent peptide MCoTI-II . mean fluorescence emission followed the trend: MCoTI-II < MCo-RM1 < MCo-CTP ~ TAT < CTP512
In vitro
CCCCTHHHHTTTCCCSSSSCCC
Additional Detail Fields 1 fields
CCCCTHHHHTTTCCCSSSSCCC