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Peptide record

TPDB61518

P5 Cell-penetrating Peptides standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB61518
P5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 21-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Nonadecanoic acid (C19) on Lys
Sequence
CPLGSYLSSSGKRSAAAAAAK-NH2
Physicochemical Analysis
C84H142N26O28S1
NDEQHIMFTWV
A
1996.27
10.20
3
0
9
+3
0.59
0.043
65.71
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
74.64
7
Residue Composition
number
6
A
1
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
0
I
2
L
2
K
0
M
0
F
1
P
5
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 6 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 2 K: 2 M: 0 F: 0 P: 1 S: 5 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C84H142N26O28S1
1996.27
10.20
+3
0.59
0.043
Amidation
Nonadecanoic acid (C19) on Lys
L
Amphiphilic
Linear
Free
N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Skbr3 Or MDA-MB-435 Cancer Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphiphilic
Synthetic
Doxorubicin (Doxo)
Cytoplasm
In vitro
CHHHHHHSSSSSCCCTHHHHC
Additional Detail Fields 1 fields
CHHHHHHSSSSSCCCTHHHHC