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Peptide record

TPDB61517

Cell-penetrating Peptides Tumor-homing Peptides standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB61517
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 TumorHoPe2.0
standard
No
A 9-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0 and TumorHoPe2.0, with an available 3D structural model.
Sequence
CPKSNNGVC
Physicochemical Analysis
C35H60N12O13S2
ARDEQHILMFTWY
NC
921.05
8.29
1
0
1
+1
2.01
-0.500
32.22
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
13.57
5
Residue Composition
number
0
A
0
R
2
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
1
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
9
C35H60N12O13S2
921.05
8.29
+1
2.01
-0.500
Evidence Records 1 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Colorectal cancer (CRC)
mono carboxylate transporter 1 (MCT1)

Source & Reference

TumorHoPe2.0
TumorHoPe2
Nanocomplexes loaded with miR-128-3p for enhancing chemotherapy effect of colorectal cancer through dual-targeting silence the activity of PI3K/AKT and MEK/ERK pathway
2020
Xin Liu et al. Drug Deliv. 2020 Dec 27. v.27(1)

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
normal colorectal epithelial cells HCoEpiC, CRC cell line HT29, HCT 116, Caco-2, SW480 cells, drug resistant HCT-15
Male Sprague Dawley (SD) rats (200±20g), specific pathogen-free male BALB/c nude mice (age of 4–5 weeks and weight of 20±2g)
Synthetic
PDMAEMA-NP
Additional Detail Fields 3 fields
PDMAEMA-NP
normal colorectal epithelial cells HCoEpiC, CRC cell line HT29, HCT 116, Caco-2, SW480 cells, drug resistant HCT-15
Male Sprague Dawley (SD) rats (200±20g), specific pathogen-free male BALB/c nude mice (age of 4–5 weeks and weight of 20±2g)