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Peptide record

TPDB61516

Cys-NLS Cell-penetrating Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB61516
Cys-NLS
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 8-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: MAL-TEG-PLL/pDNA micelle N-terminal: Addition of Cysteine
Sequence
CPKKKRKV
Physicochemical Analysis
C43H83N15O9S1
ANDEQGHILMFSTWY
K
986.29
10.98
5
0
1
+5
5.05
-1.875
36.25
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
1
C
0
E
0
Q
0
G
0
H
0
I
0
L
4
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
8
C43H83N15O9S1
986.29
10.98
+5
5.05
-1.875
Free
MAL-TEG-PLL/pDNA micelle
L
Cationic
Linear
Addition of Cysteine
N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Leaves Of N. Benthamiana

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
pDNA (p35S-Nluc-tNOS)
No significant difference of gene delivery efficiency was observed between NLS-48 (437 ± 158 RLU/mg) and unmodified micelles (794 ± 249 RLU/mg)
In vitro
CGGGGGTHHHHC
Additional Detail Fields 1 fields
CGGGGGTHHHHC