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Peptide record

TPDB61515

MCoTI-II Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB61515
MCoTI-II
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CPKILKKCRRDSDCPGACICRGNGYCGSGSDGGV
Physicochemical Analysis
C138H231N47O46S6
EQHMFTW
G
3477.00
8.31
6
3
6
+3
7.21
-0.444
45.88
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1865
53.64
11
Residue Composition
number
1
A
3
R
1
N
3
D
6
C
0
E
0
Q
7
G
0
H
2
I
1
L
3
K
0
M
0
F
2
P
3
S
0
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 3 C: 6 E: 0 Q: 0 G: 7 H: 0 I: 2 L: 1 K: 3 M: 0 F: 0 P: 2 S: 3 T: 0 W: 0 Y: 1 V: 1
Chemical Descriptors
34
C138H231N47O46S6
3477.00
8.31
+3
7.21
-0.444
Free
L
Cyclic
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L
Synthetic
Alexa fluor® 488 at Lys
Cytoplasm
Mean fluorescence emission followed the trend: MCoTI-II < MCo-RM1 < MCo-CTP ~ TAT < CTP512
In vitro
CCCCCC
Additional Detail Fields 1 fields
CCCCCC