Back to search

Peptide record

TPDB61511

NGR Cell-penetrating Peptides Tumor-homing Peptides standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61511
NGR
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
PerseuCPP TumorHoPe2.0
standard
No
A 6-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from PerseuCPP and TumorHoPe2.0, with an available 3D structural model.
Sequence
CNGRCG
Physicochemical Analysis
C20H36N10O8S2
ADEQHILKMFPSTWYV
CG
608.69
8.30
1
0
0
+1
0.77
-0.633
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
20.54
3
Residue Composition
number
0
A
1
R
1
N
0
D
2
C
0
E
0
Q
2
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C20H36N10O8S2
608.69
8.30
+1
0.77
-0.633
Evidence Records 2 records
Evidence 1 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Endothelial cell, Tumor vessel
Homing
Lung cancer
VEGF

Source & Reference

TumorHoPe2.0
TumorHoPe2
NGR-TNF, a novel vascular-targeting agent, does not induce cytokine recruitment of proangiogenic bone marrow-derived cells
2013
P Di Matteo et al. Br J Cancer. 2013 Jul 23 109(2):360-9.

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Lewis lung carcinoma (LLC) and 4T1 cell line
BALB/c mice, C57BL/6 mice
Cy3, FITC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Homing
tumor metastasis

Source & Reference

TumorHoPe2.0
TumorHoPe2
2015
Di Matteo P et al. Clin Exp Metastasis. 2015 Mar 32(3):289-300.

Other

TNF-α
Additional Detail Fields 3 fields
Cy3, FITC TNF-α
Lewis lung carcinoma (LLC) and 4T1 cell line
BALB/c mice, C57BL/6 mice