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Peptide record

TPDB61510

NGR Cell-penetrating Peptides Tumor-homing Peptides standard
5 amino acids
Basic Information
3D PDB MODEL
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TPDB61510
NGR
Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 5-aa standard natural multi-activity (Cell-penetrating Peptides and Tumor-homing Peptides) peptide sequence curated from CPPsite3.0, Peptipedia, PerseuCPP, and other sources, with an available 3D structural model.
Sequence
CNGRC
Physicochemical Analysis
C18H33N9O7S2
ADEQHILKMFPSTWYV
C
551.64
8.30
1
0
0
+1
0.76
-0.680
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
22.66
3
Residue Composition
number
0
A
1
R
1
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C18H33N9O7S2
551.64
8.30
+1
0.76
-0.680
Free
L
Linear
NGR
Free
N[C@@H](CS)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 8 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs and 4T1

Assay & Model

Female BALB/c mice
Female BALB/c mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Small molecule drug (Doxorubicin) and Fluorophore (FAM)
In vitro and in vivo
CCSCC
Evidence 2 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell,
Homing
gC1q/p32 receptor

Source & Reference

TumorHoPe2.0
TumorHoPe2
Targeted delivery system and methods of use therefor
2022
US 11512110 B2
US 11512110 B2

Other

Source Activity Label Source Definition
Tumor-homing Peptides
TumorHoPe2.0 experimentally validated tumor-homing peptide annotation.
Athymic nude mice, ApoE null mice
Phage display library
T7 phage / cyclic Cx7C and linear X7 peptide library
Nanoworms(NWs), polyethylene glycol
Evidence 3 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell, Tumor vessel, Tumor stem cell, Endothelial cell, Epithelial cell, Dendritic cell
Homing

Source & Reference

TumorHoPe2.0
TumorHoPe2
Methods and compositions using peptides and proteins with C-terminal elements
2019
US 10370245 B2
US 10370245 B2

Other

PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line
BALB/c athymic nude mice
Phage Display library
T7 phage display library
nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide]
Evidence 4 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Breast cancer, Squamous cell carcinoma, Colon carcinoma
vimentin

Source & Reference

TumorHoPe2.0
TumorHoPe2
Carcinoma homing peptide (CHP), its analogs, and methods of using
2017
US 9657077 B2
US 9657077 B2

Other

SCCVII, CT26, 4T1, and B16F10 cell line
C57B1/6 mice, C3H mice, Nude mice, wtIL-12−/− mice, female Balb/c mice (all are six to eight weeks old)
Phage Display library
interleukin 12 (IL-12)
cyclic
Evidence 5 Activity

Activity

Tumor-homing Peptides

Target

Endothelial cell, Tumor vessel
Homing
Breast cancer, Hepatocellular Liver carcinoma
CD13

Source & Reference

TumorHoPe2.0
TumorHoPe2
An NGR-integrated and enediyne-energized apoprotein shows CD13-targeting antitumor activity
2013
Yan-bo Zheng et al. Biomed Pharmacother. 2013 Mar. 67(2):164-71

Other

Human fibrosarcoma HT-1080 cells, human breast cancer MCF 7 cells, human hepatocellular liver carcinoma HepG2
female Kunming mice (18–22 g), female BALB/c nude mice (18–22g)
Synthetic
Lidamycin
Evidence 6 Activity

Activity

Tumor-homing Peptides

Target

Tumor cell
Homing
Aminopeptidase N

Source & Reference

TumorHoPe2.0
TumorHoPe2
NGR Tumor-Homing Peptides: Structural Requirements for Effective APN (CD13) Targeting
2016
Alessandra Graziadio et al. Bioconjug Chem. 2016 May 18 27(5):1332-40.

Other

Synthetic
biotin affinity tag or a fluorescent tag
Cyclic
Evidence 7 Activity

Activity

Tumor-homing Peptides

Target

Homing
Alpha -5, Beta -3 integrin

Source & Reference

TumorHoPe2.0
TumorHoPe2
NGR-tagged nano-gold: A new CD13-selective carrier for cytokine delivery to tumors
2016
Curnis F et al. Nano Res. 2016 May 9(5):1393-1408

Other

MCF-7, Murine WEHI-164 fibrosarcoma cells
WEHI-164 tumor bearing mice
Synthetic
HSA
Evidence 8 Activity

Activity

Tumor-homing Peptides

Target

Homing
Hepatocellular carcinoma

Source & Reference

TumorHoPe2.0
TumorHoPe2
2015
Ma J et al. Curr Cancer Drug Targets. 2015 15(6):533-41.

Other

Hep3B cells
sR9-wtNIP
Additional Detail Fields 5 fields
Nanoworms(NWs), polyethylene glycol nanoparticles, nanoworms, 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[maleimide(polyethylene glycol)2000 DSPE-PEG2000-maleimide] interleukin 12 (IL-12) Lidamycin biotin affinity tag or a fluorescent tag HSA sR9-wtNIP
CCSCC
PPC-1, PC-3, Du-145, 4T1, MIA PaCa-2, PDAC1.3, B16F10, M21, and MDA-MB-435 cell line SCCVII, CT26, 4T1, and B16F10 cell line Human fibrosarcoma HT-1080 cells, human breast cancer MCF 7 cells, human hepatocellular liver carcinoma HepG2 MCF-7, Murine WEHI-164 fibrosarcoma cells Hep3B cells
Athymic nude mice, ApoE null mice BALB/c athymic nude mice C57B1/6 mice, C3H mice, Nude mice, wtIL-12−/− mice, female Balb/c mice (all are six to eight weeks old) female Kunming mice (18–22 g), female BALB/c nude mice (18–22g) WEHI-164 tumor bearing mice
T7 phage / cyclic Cx7C and linear X7 peptide library T7 phage display library