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Peptide record

TPDB61505

Mgpe-10 Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61505
Mgpe-10
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, MLCPP 2.0, Peptipedia, and other sources, with an available 3D structural model.
Chemical: Addition of cysteine in Mgpe4 sequence makes Mgpe10
Sequence
CLLYWFRRRHRHHRRRHRRC
Physicochemical Analysis
C125H198N56O22S2
ANDEQGIKMPSTV
R
2901.43
12.50
13
0
5
+9
5.61
-2.005
39.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
7115
245.22
3
Residue Composition
number
0
A
9
R
0
N
0
D
2
C
0
E
0
Q
0
G
4
H
0
I
2
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 2 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
20
C125H198N56O22S2
2901.43
12.50
+9
5.61
-2.005
Free
Addition of cysteine in Mgpe4 sequence makes Mgpe10
L
Amphipathic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549, MCF-7, HeLa, HEK, T47D, B16, MDA-MB 231, B35 and U 87, CHO-K1, H-1299, JURKAT and RAW

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
Nucleic acid (Plasmid DNA)
Less efficient peptide for DNA uptake (comparison to Mgpe-4)
In vitro
CCCHHHHHSCSCCCCC
Additional Detail Fields 1 fields
CCCHHHHHSCSCCCCC