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Peptide record

TPDB61504

CPP4 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB61504
CPP4
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: IR780-labeled usNLCs
Sequence
CLLLLLRRRLRKQAHAHSK-NH2
Physicochemical Analysis
C101H182N38O22S1
NDEGIMFPTWYV
L
2312.86
12.41
8
0
8
+6
3.91
-0.400
133.68
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
4
R
0
N
0
D
1
C
0
E
1
Q
0
G
2
H
0
I
6
L
2
K
0
M
0
F
0
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 0 H: 2 I: 0 L: 6 K: 2 M: 0 F: 0 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
19
C101H182N38O22S1
2312.86
12.41
+6
3.91
-0.400
Amidation
IR780-labeled usNLCs
L
Linear
Free
N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hbmec Cell Monolayer And U87 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Celecoxib (CXB)
CPP4 (Papp= 7.3±2.9 ×10-5 cm/s) promote a higher drug transport across the BBB.
Non-dependent energy pathway (e.g., direct translocation).
In vitro and ex vivo
CCSCSCSCCC
Additional Detail Fields 1 fields
CCSCSCSCCC