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Peptide record

TPDB61503

Dox-pVEC-gHo (Dox- gHoPe2) Cell-penetrating Peptides standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB61503
Dox-pVEC-gHo (Dox- gHoPe2)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 31-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Succinimidyl-4-(N-mal-eimidomethyl) cyclohexane-1-carboxylate (SMCC)
Sequence
CLLIILRRRIRKQAHAHSKNHQQQNPHQPPM-NH2
Physicochemical Analysis
C161H270N60O40S2
DEGFTWYV
Q
3750.41
12.41
10
0
9
+6
10.86
-1.155
81.94
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
9
Residue Composition
number
2
A
4
R
2
N
0
D
1
C
0
E
5
Q
0
G
4
H
3
I
3
L
2
K
1
M
0
F
3
P
1
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 4 N: 2 D: 0 C: 1 E: 0 Q: 5 G: 0 H: 4 I: 3 L: 3 K: 2 M: 1 F: 0 P: 3 S: 1 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
31
C161H270N60O40S2
3750.41
12.41
+6
10.86
-1.155
Amidation
L
Linear
Succinimidyl-4-(N-mal-eimidomethyl) cyclohexane-1-carboxylate (SMCC)
N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HEK 293, human glioma, U87 MG and HeLa

Assay & Model

Female nude mice
Female nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Small molecule drug (Doxorubicin)
In vitro and in vivo
CGGGGGGGGGGGTSSSSSSSSCCSTTC
Additional Detail Fields 1 fields
CGGGGGGGGGGGTSSSSSSSSCCSTTC