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Peptide record

TPDB61501

leucine (L)- and lysine (K)-rich Cell-penetrating Peptides standard
34 amino acids
Basic Information
3D PDB MODEL
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TPDB61501
leucine (L)- and lysine (K)-rich
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 34-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: bumpy Au triangular nanoprisms (BATrisms) N-terminal: Acetylation
Sequence
Ac-CLKKLLKLLKKLLKLGGLKKLLKLLKKLLKLAGC
Physicochemical Analysis
C183H346N46O35S2
RNDEQHIMFPSTWYV
L
3815.17
10.99
12
0
17
+12
2.30
0.576
186.47
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
3.28
2
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
0
Q
3
G
0
H
0
I
16
L
12
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 16 K: 12 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
34
C183H346N46O35S2
3815.17
10.99
+12
2.30
0.576
Free
bumpy Au triangular nanoprisms (BATrisms)
L
Amphipathic
Linear
Acetylation
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MDA-MB-231 cells

Assay & Model

Xenograft mice model of Balb/c nude mice (5 weeks ages with around 20 g)
Xenograft mice model of Balb/c nude mice (5 weeks ages with around 20 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Amphipathic
Synthetic
5(6)-carboxytetramethylrhodamine (TAMRA)-
Endosomes
LK-BATrism showed 13 times higher cellular uptake (0.73ppb/cell) compared to the mPEG-BATrism
In vitro and in vivo
CCTHHHHTTCC
Additional Detail Fields 1 fields
CCTHHHHTTCC