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Peptide record

TPDB61498

hsTPT Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB61498
hsTPT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CLIHHALAALAHLNIHLLYGASNLTWG
Physicochemical Analysis
C135H208N38O33S1
RDEQKMFPV
L
2923.43
7.47
4
0
16
+0
-3.45
0.844
148.52
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
6990
239.10
6
Residue Composition
number
5
A
0
R
2
N
0
D
1
C
0
E
0
Q
2
G
4
H
2
I
7
L
0
K
0
M
0
F
0
P
1
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 5 R: 0 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 4 I: 2 L: 7 K: 0 M: 0 F: 0 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
27
C135H208N38O33S1
2923.43
7.47
+0
-3.45
0.844
Free
L
Linear
Free
N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Freestyletm 293-F Cells And Red Blood Cell Membranes

Assay & Model

BALB/c nude mice
BALB/c nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Increased membrane perturbation activity at pH 6.0 (early endosome pH) and pH 5.5 (late endosome pH).
In vitro and in vivo
CCSCCCSCCCCCCCSSCCCC
Additional Detail Fields 1 fields
CCSCCCSCCCCCCCSSCCCC