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Peptide record

TPDB61494

cys-H6R6 Cell-penetrating Peptides standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB61494
cys-H6R6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 19-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Nanocomposite (CS-g-PNVCL) N-terminal: Addition of Cysteine
Sequence
CKVRVRVRVDPTRVRERVK
Physicochemical Analysis
C99H183N39O25S1
ANQGHILMFSWY
RV
2351.85
12.12
8
2
6
+6
10.86
-0.863
91.58
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
1
D
1
C
1
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
1
P
0
S
1
T
0
W
0
Y
6
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 1 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 6
Chemical Descriptors
19
C99H183N39O25S1
2351.85
12.12
+6
10.86
-0.863
Free
Nanocomposite (CS-g-PNVCL)
L
Linear
Addition of Cysteine
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HUVEC Cells And Skov3 Cells

Assay & Model

Female nude mice (4–5 weeks old) and Sprague-Dawley (SD) rats
Female nude mice (4–5 weeks old) and Sprague-Dawley (SD) rats

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Doxorubicin (DOX) and oleanolic acid (OA)
Red fluorescence signals of HUVEC cells incubated with (DOX/OA)@CS-g-PNVCL and (DOX/OA)@H6R6-CS-g-PNVCL were quite weak. However, SKOV3 cells incubated with (DOX/OA)@H6R6-CS-g-PNVCL exhibited a much higher red fluorescence signal compared to those treated with (DOX/OA)@CS-g-PNVCL, indicating that H6R6-functionalized NPs could target tumor cells, rather than normal cells
In vitro and in vivo
CCSSCSSCC
Additional Detail Fields 1 fields
CCSSCSSCC