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Peptide record

TPDB61491

GBP1–linR10 (2E) Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB61491
GBP1–linR10 (2E)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Addition of Cysteine
Sequence
CKRRRRRRRRRRRE
Physicochemical Analysis
C80H158N48O17S1
ANDQGHILMFPSTWYV
R
2096.51
12.83
12
1
0
+11
11.68
-3.886
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
11
R
0
N
0
D
1
C
1
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 11 N: 0 D: 0 C: 1 E: 1 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C80H158N48O17S1
2096.51
12.83
+11
11.68
-3.886
Free
L and D
Cationic
Linear
Addition of Cysteine
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

3T3 Gfp And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L and D Cationic
Synthetic
GFP-binding nanobodies (GBP1) at N terminus
Nucleolus
Cyclic CPP are more efficient in cellular uptake than the linear versions and the R10 peptides are more efficient than the TAT peptides.
In vitro
CCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCCCCCCC