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Peptide record

TPDB61483

Compound 4 Compound 5 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB61483
Compound 4 Compound 5
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
CKRKGCGSGSC-NH2
Physicochemical Analysis
C39H72N16O14S3
ANDEQHILMFPTWYV
CG
1085.28
9.21
3
0
0
+3
2.36
-0.691
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
11.52
5
Residue Composition
number
0
A
1
R
0
N
0
D
3
C
0
E
0
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C39H72N16O14S3
1085.28
9.21
+3
2.36
-0.691
Amidation
L
Cationic
Bicyclic
Free
N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mda, HeLa, A549 Cells And Ht-29 Human Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Bicyclic L Cationic
Synthetic
RhB (rhodamine B with piperazine linker) at N terminus
7.1 microMolar uptake in HeLa cells relative to TAT 1 μM
Macropinocytosis
In vitro
CCCCSCCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Mda, HeLa, A549 Cells And Ht-29 Human Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Bicyclic L Cationic
Synthetic
RhB (rhodamine B with piperazine linker) at N terminus
1.5 microMolar uptake in HeLa cells relative to TAT 1 μM
Macropinocytosis
In vitro
CCBCSSSBCCC
Additional Detail Fields 1 fields
CCCCSCCCCCC CCBCSSSBCCC