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Peptide record

TPDB61480

Compound 1 Compound 2 Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB61480
Compound 1 Compound 2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 11-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
CKRKGCGKRKC-NH2
Physicochemical Analysis
C49H95N21O12S3
ANDEQHILMFPSTWYV
K
1266.61
10.55
6
0
0
+6
4.88
-1.627
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
9.87
3
Residue Composition
number
0
A
2
R
0
N
0
D
3
C
0
E
0
Q
2
G
0
H
0
I
0
L
4
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 2 H: 0 I: 0 L: 0 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C49H95N21O12S3
1266.61
10.55
+6
4.88
-1.627
Amidation
L
Cationic
Bicyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Mda, HeLa, A549 Cells And Ht-29 Human Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Bicyclic L Cationic
Synthetic
RhB (rhodamine B with piperazine linker) at N terminus
7.7 microMolar uptake in HeLa cells relative to TAT 1 μM
Macropinocytosis
In vitro
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Mda, HeLa, A549 Cells And Ht-29 Human Cell Lines

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Bicyclic L Cationic
Synthetic
RhB (rhodamine B with piperazine linker) at N terminus
4.3 microMolar uptake in HeLa cells relative to TAT 1 μM
Macropinocytosis
In vitro
CCCCSSCCSCC
Additional Detail Fields 1 fields
CCCCSSCCSCC