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Peptide record

TPDB61477

dNP2 Cell-penetrating Peptides standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB61477
dNP2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 23-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer
Sequence
CKIKKVKKKGRKKIKKVKKKGRK
Physicochemical Analysis
C125H245N43O24S1
ANDEQHLMFPSTWY
K
2766.65
11.93
16
0
4
+16
14.78
-1.935
59.13
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
2
R
0
N
0
D
1
C
0
E
0
Q
2
G
0
H
2
I
0
L
14
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 0 K: 14 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
23
C125H245N43O24S1
2766.65
11.93
+16
14.78
-1.935
Free
N-(2-hydroxypropyl)-methacrylamide (HPMA) copolymer
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Doxorubicin
Nucleus
P-(dNP2)-DOX had a significantly 1.54 fold higher cellular uptake than P-DOX.
Endocytosis
In vitro
CTTHHHHGGGGGGHHHHTTCCCC
Additional Detail Fields 1 fields
CTTHHHHGGGGGGHHHHTTCCCC