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Peptide record

TPDB61474

rT1 Cell-penetrating Peptides standard
27 amino acids
Basic Information
3D PDB MODEL
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TPDB61474
rT1
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 27-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with Cyanine 3 (Cy3)
Sequence
CIPRGGICLVALSGCCNSPGCIFGICA
Physicochemical Analysis
C110H183N31O31S6
DEQHKMTWY
C
2628.21
7.63
1
0
10
+1
-2.76
1.348
104.81
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
375
14.27
9
Residue Composition
number
2
A
1
R
1
N
0
D
6
C
0
E
0
Q
5
G
0
H
4
I
2
L
0
K
0
M
1
F
2
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 0 C: 6 E: 0 Q: 0 G: 5 H: 0 I: 4 L: 2 K: 0 M: 0 F: 1 P: 2 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
27
C110H183N31O31S6
2628.21
7.63
+1
-2.76
1.348
Free
L
Cationic and hydrophobic
Linear
Conjugated with Cyanine 3 (Cy3)
N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Wi-38 And HUVEC-Cs Cells THP-1 And Jurkat Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic and hydrophobic
Protein derived
Cyanine 3 dye
Mitochondria
Incubation with 1 M Cy3-rT1 in all cell lines resulted in increased fluorescence intensity of the cell population and reached a plateau in 1h, suggesting cellular uptake of Cy3-rT1 is not cell-type specific.
Clathrin mediated endocytosis
In vitro
CCSSCC
Additional Detail Fields 1 fields
CCSSCC