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Peptide record

TPDB61472

AAM-2 Cell-penetrating Peptides standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB61472
AAM-2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 26-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation
Sequence
CIGAVLHVLTTGLPALISWIHHHHQQ-NH2
Physicochemical Analysis
C132H205N39O32S1
RNDEKMFY
H
2882.38
7.53
5
0
12
+0
1.38
0.565
135.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
5500
190.81
6
Residue Composition
number
2
A
0
R
0
N
0
D
1
C
0
E
2
Q
2
G
5
H
3
I
4
L
0
K
0
M
0
F
1
P
1
S
2
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 2 G: 2 H: 5 I: 3 L: 4 K: 0 M: 0 F: 0 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 2
Chemical Descriptors
26
C132H205N39O32S1
2882.38
7.53
+0
1.38
0.565
Amidation
L
Linear
Free
NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16-F10 Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
FAM via a thioether bond to the cysteine
Endosomes
FAM-AAM-2 weakly exhibited cell-penetrating activity.
In vitro
CCGGGCSTTTSSGGGGGTCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

B16-F10 Cells

Assay & Model

Six-week-old female C57BL/6 mice
Six-week-old female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
CPT (via disulfide-releasing carbonate linker)
Endosomes
Fluorescence intensity in CPT-AAM-2-treated cells at pH 5.5 was stronger than that at pH 7.4,
In vitro and in vivo
CCGGGCSTTTSSGGGGGTCCC
Additional Detail Fields 1 fields
CCGGGCSTTTSSGGGGGTCCC