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Peptide record

TPDB61468

CH2R4H2C cytoplasm-responsive peptide Cell-penetrating Peptides standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB61468
CH2R4H2C cytoplasm-responsive peptide
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP
standard
No
A 10-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
Chemical: Nano-micelle (MPEG-PCL)
Sequence
CHHRRRRHHC
Physicochemical Analysis
C54H88N30O11S2
ANDEQGILKMFPSTWYV
RH
1397.61
11.93
8
0
0
+4
6.60
-2.580
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
8.94
2
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
4
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 4 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C54H88N30O11S2
1397.61
11.93
+4
6.60
-2.580
Free
Nano-micelle (MPEG-PCL)
L
Linear
Free
N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

B16F10 Cells And Rpe-J Cell Lines

Assay & Model

Lung metastasis mouse model (Six-week-old male C57BL/6 mice)
Lung metastasis mouse model (Six-week-old male C57BL/6 mice)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Anti-RelA siRNA (siRelA)
Cytoplasm
The siRNA cellular uptake percentage (%) indicated a high uptake ability that was above 90% compared to naked siRNA groups.
In vitro and in vivo
CTTHHHHHHHHHHHHHHHHHHHHGGGGTTTCC
Additional Detail Fields 1 fields
CTTHHHHHHHHHHHHHHHHHHHHGGGGTTTCC