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Peptide record

TPDB61464

HL6 Cell-penetrating Peptides standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB61464
HL6
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 18-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Conjugated with FITC
Sequence
CHHHHHRRWQWRHHHHHC
Physicochemical Analysis
C111H146N50O20S2
ANDEGILKMFPSTYV
H
2564.82
10.82
13
0
2
+4
8.43
-2.544
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11125
433.75
3
Residue Composition
number
0
A
3
R
0
N
0
D
2
C
0
E
1
Q
0
G
10
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 0 H: 10 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
18
C111H146N50O20S2
2564.82
10.82
+4
8.43
-2.544
Free
L
Cationic
Linear
Conjugated with FITC
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549 And HeLa Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Fusogenic
FITC dye and quantum dots (QDs)
46.7 times higher than in the FITC-L6 group at 60min
Direct membrane translocation , macropinocytosis and clathrin-dependent endocytosis
In vitro