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Peptide record

TPDB61459

(HE)10-G5-R6 [or HE-R6] Cell-penetrating Peptides standard
32 amino acids
Basic Information
3D PDB MODEL
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TPDB61459
(HE)10-G5-R6 [or HE-R6]
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 32-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CHEHEHEHEHEHEHEHEHEHEGGGGGRRRRRR
Physicochemical Analysis
C159H234N70O53S1
ANDQILKMFPSTWYV
EH
4006.10
6.20
16
10
0
-3
34.47
-2.922
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
10
E
0
Q
5
G
10
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 10 Q: 0 G: 5 H: 10 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
32
C159H234N70O53S1
4006.10
6.20
-3
34.47
-2.922
Free
L
Cationic
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

4T1 Cell Line

Assay & Model

4T1 tumor-bearing Balb/C mice (female, 18–20 g), Sprague Dawley (SD) rats (female, 200 ± 20 g, SPF grade) and New Zealand rabbits (female, 1.8–2.0 kg
4T1 tumor-bearing Balb/C mice (female, 18–20 g), Sprague Dawley (SD) rats (female, 200 ± 20 g, SPF grade) and New Zealand rabbits (female, 1.8–2.0 kg

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Artemisinin (ART)
Mice receiving Lip-HE-R6 had the highest fluorescence in the tumor area, which was 1.65-, 6.19-, and 8.75-fold higher than that of DiR-loaded Lip-R6, Lip-mPEG, and free DiR, respectively
Endocytosis, including clathrin-dependent endocytosis, electrostatic adsorption-mediated endocytosis
In vitro and in vivo
CCSSSSSCSCCSSSCCCCCCCC
Additional Detail Fields 1 fields
CCSSSSSCSCCSSSCCCCCCCC