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Peptide record

TPDB61446

T7-LP Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides standard
8 amino acids
Basic Information
3D PDB MODEL
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TPDB61446
T7-LP
Blood-Brain Barrier Cell-penetrating Peptides Tumor-homing Peptides
Cancer-related peptides Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0 MLCPP 2.0 Peptipedia PerseuCPP TumorHoPe2.0
standard
No
A 8-aa standard natural multi-activity (Blood-Brain Barrier, Cell-penetrating Peptides, and Tumor-homing Peptides) peptide sequence curated from BBPpredict, CPPsite3.0, MLCPP 2.0, and other sources, with an available 3D structural model.
C-terminal: Conjugation with rhodamine LP
Sequence
CHAIYPRH
Physicochemical Analysis
C44H65N15O10S1
NDEQGLKMFSTWV
H
996.15
8.91
3
0
3
+1
1.52
-0.625
61.25
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
149.58
2
Residue Composition
number
1
A
1
R
0
N
0
D
1
C
0
E
0
Q
0
G
2
H
1
I
0
L
0
K
0
M
0
F
1
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
8
C44H65N15O10S1
996.15
8.91
+1
1.52
-0.625
Conjugation with rhodamine LP
L
Linear
Free
N[C@@H](CS)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549

Assay & Model

BALB/c male athymic nude mice
BALB/c male athymic nude mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
Nanoparticle (Liposome)
Cytoplasm and nucleus
Higher uptake efficiency
Clathrin mediated endocytosis
In vitro and in vivo
CCSSCC
Additional Detail Fields 1 fields
CCSSCC