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Peptide record

TPDB61445

FAM-CGY Blood-Brain Barrier Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB61445
FAM-CGY
Blood-Brain Barrier Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
BBPpredict CPPsite3.0
standard
No
A 16-aa standard natural multi-activity (Blood-Brain Barrier and Cell-penetrating Peptides) peptide sequence curated from BBPpredict and CPPsite3.0, with an available 3D structural model.
Chemical: 5-FAM at N terminal
Sequence
CGYRPVHNIRGHWAPG
Physicochemical Analysis
C81H118N28O19S1
DEQLKMFST
G
1820.06
9.90
4
0
5
+2
1.45
-0.781
48.75
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
6990
384.05
3
Residue Composition
number
1
A
2
R
1
N
0
D
1
C
0
E
0
Q
3
G
2
H
1
I
0
L
0
K
0
M
0
F
2
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 1 R: 2 N: 1 D: 0 C: 1 E: 0 Q: 0 G: 3 H: 2 I: 1 L: 0 K: 0 M: 0 F: 0 P: 2 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
16
C81H118N28O19S1
1820.06
9.90
+2
1.45
-0.781
Free
5-FAM at N terminal
L
Amphiphilic
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Male and females (50:50 distribution) ICR mice (6–8 weeks old, body weight 20–26 g)
Male and females (50:50 distribution) ICR mice (6–8 weeks old, body weight 20–26 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Amphiphilic
Protein derived
Cy3-siRNA
Early Endosomes And Lysosomal Compartments
Poor uptake of free Cy3-labelled siRNA by hCMEC/D3 cells, whereas Cy3-siRNA was successfully taken up through nanofibre formed between FAM-CGY and siRNA delivery
Macropinocytosis
In vivo