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Peptide record

TPDB61442

TAT Cell-penetrating Peptides standard
15 amino acids
Basic Information
3D PDB MODEL
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TPDB61442
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 15-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, Peptipedia, and PerseuCPP, with an available 3D structural model.
Sequence
CGYGRKKRRQRRRGC
Physicochemical Analysis
C74H134N36O18S2
ANDEHILMFPSTWV
R
1880.23
12.12
8
0
1
+8
6.03
-2.387
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1615
85.89
4
Residue Composition
number
0
A
6
R
0
N
0
D
2
C
0
E
1
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
15
C74H134N36O18S2
1880.23
12.12
+8
6.03
-2.387
Free
L
Cationic
Cyclic Linear
Free
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Evidence Records 2 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Hypoxia human umbilical vein endothelial cell (HUVEC)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Protein derived
Nucleic acid (pDNA)
In vitro
CCCSTTGGGGGTSCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

HUVECs

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Protein derived
Ultrasound contrast agent (UCA), Fluorophore (FITC)
Confocal laser scanning microscopy (CLSM) showed that gene and CPP were distributed on the shell of UCA
In vitro
CCCSTTGGGGGTSCC
Additional Detail Fields 1 fields
CCCSTTGGGGGTSCC