Back to search

Peptide record

TPDB61439

TAT-Cys (or CGSSG-TAT) Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB61439
TAT-Cys (or CGSSG-TAT)
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Polydopamine (PDA) and PEGylation
Sequence
CGSSGYGRKKRRQRRR
Physicochemical Analysis
C77H139N37O21S1
ANDEHILMFPTWV
R
1951.25
12.41
8
0
1
+8
6.53
-2.494
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
76.36
5
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
2
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
16
C77H139N37O21S1
1951.25
12.41
+8
6.53
-2.494
Free
Polydopamine (PDA) and PEGylation
L
Linear
Free
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Tc-1 Cells

Assay & Model

Female C57BL/6 mice
Female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Docetaxel loaded C6-labeled nanocrystals (NC)
Perinuclear Region (In Cytoplasm)
Intracellular DTX concentration of NC@PDA-PEG-TAT, NC@PDA-PEG, NC@PDA, NC and bulk DTX were 15.99 ± 1.71 μg, 5.42 ± 0.51 μg, 6.32 ± 0.17 μg, 2.40 ± 0.23 μg and 10.25 ± 3.16 μg/106 cells, respectively
In vitro and in vivo
CCSGGGCCSCC
Additional Detail Fields 1 fields
CCSGGGCCSCC