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Peptide record

TPDB61427

TAT/PB Cell-penetrating Peptides standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB61427
TAT/PB
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 12-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: pyrenebutyrate (PB)
Sequence
CGRKKRRQRRRK
Physicochemical Analysis
C64H126N34O14S1
ANDEHILMFPSTWYV
R
1627.98
12.71
9
0
0
+9
8.18
-3.342
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
1
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
12
C64H126N34O14S1
1627.98
12.71
+9
8.18
-3.342
Free
pyrenebutyrate (PB)
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Skin From The Abdominal Surface Of Wister Rats

Assay & Model

Kunming mice (6 to 8-weeks-old) and Wistar rats (9 to 11-weeks-old)
Kunming mice (6 to 8-weeks-old) and Wistar rats (9 to 11-weeks-old)

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nanostructured lipid carriers (NLC) loaded with lidocaine hydrochloride (LID)
TAT/PB LID NLC (851.2 ± 25.3 µg/cm2) showed better percutaneous penetration ability than PB LID NLC (610.7 ± 22.1 µg/cm2) and TAT LID NLC (551.9 ± 21.8 µg/cm2)
In vitro and in vivo
CCCSSSTTCCCTTTTC
Additional Detail Fields 1 fields
CCCSSSTTCCCTTTTC