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Peptide record

TPDB61410

GXC Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB61410
GXC
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CGNSNPKSCRPAKPAR
Physicochemical Analysis
C67H116N26O21S2
DEQHILMFTWYV
P
1685.94
10.58
4
0
2
+4
5.24
-1.375
12.50
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
7.41
6
Residue Composition
number
2
A
2
R
2
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
0
F
3
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 2 N: 2 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 3 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C67H116N26O21S2
1685.94
10.58
+4
5.24
-1.375
Free
L
Linear
Free
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sgc-7901 Cells.

Assay & Model

Orthotopic SGC-7901 xenograft models (4−6-week-old male nude mice (20−25 g))
Orthotopic SGC-7901 xenograft models (4−6-week-old male nude mice (20−25 g))

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L
Synthetic
Adriamycin (ADR) and FITC-labeled
Co-administrated with peptides (GXC/RPAKPAR) leads to significantly higher intracellular ADR concentrations (red fluorescence) than that in GX1 group or ADR alone
In vitro and in vivo