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Peptide record

TPDB61408

CGN Cell-penetrating Peptides standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB61408
CGN
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 13-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Chemical: Targeting ligand mannose (MAN)
Sequence
CGNHPHLAKYNGT
Physicochemical Analysis
C60H90N20O18S1
RDEQIMFSWV
NGH
1411.56
8.89
3
0
3
+1
2.45
-1.046
37.69
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
105.56
5
Residue Composition
number
1
A
0
R
2
N
0
D
1
C
0
E
0
Q
2
G
2
H
0
I
1
L
1
K
0
M
0
F
1
P
0
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 1 E: 0 Q: 0 G: 2 H: 2 I: 0 L: 1 K: 1 M: 0 F: 0 P: 1 S: 0 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
13
C60H90N20O18S1
1411.56
8.89
+1
2.45
-1.046
Free
Targeting ligand mannose (MAN)
L
Linear
Free
N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(=O)N)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)N)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Primary Neurons, bEnd.3 Cells, And Primary Astrocytes.

Assay & Model

Male and female C57BL/6 mice
Male and female C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Phage Display
pVGF/chitosan complex
Post 4 h of incubation, the bifunctionalized liposomes (RVG9RMAN, RDPMAN and CGNMAN) were found to be internalized in excess of 80% in primary neurons, bEnd.3 cells, and primary astrocytes.
In vitro and in vivo
CCSSSSCCSCC
Additional Detail Fields 1 fields
CCSSSSCCSCC