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Peptide record

TPDB61406

TAT Cell-penetrating Peptides standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB61406
TAT
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 14-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
N-terminal: Addition of Cysteine
Sequence
CGGYGRKKRRQRRR
Physicochemical Analysis
C71H129N35O17S1
ANDEHILMFPSTWV
R
1777.09
12.41
8
0
1
+8
6.27
-2.736
0.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
1490
83.84
3
Residue Composition
number
0
A
6
R
0
N
0
D
1
C
0
E
1
Q
3
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
14
C71H129N35O17S1
1777.09
12.41
+8
6.27
-2.736
Free
L
Linear
Addition of Cysteine
N[C@@H](Cc1ccccc1)C(=O)/N=C/C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Ns3-Huh7 Cell Lines

Assay & Model

Huh7 cells xenograft of 5 week old BALB/c nude male mice
Huh7 cells xenograft of 5 week old BALB/c nude male mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Protein derived
Au−Te-clustered nanoworms (AuTeNWs)
Enhanced cell penetration imparted by the TAT peptide.
In vitro and in vivo
CCTTSSCCCCC
Additional Detail Fields 1 fields
CCTTSSCCCCC