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Peptide record

TPDB61404

b-WT1-pTj Cell-penetrating Peptides standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB61404
b-WT1-pTj
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CellPPD-MOD CPPsite3.0 Peptipedia PerseuCPP
standard
No
A 30-aa standard natural cell-penetrating peptides peptide sequence curated from CellPPD-MOD, CPPsite3.0, Peptipedia, and other sources, with an available 3D structural model.
C-terminal: Amidation N-terminal: Biotinylation
Sequence
CGGKDCERRFSRSDQLKRHQRRHTGVKPFQ-NH2
Physicochemical Analysis
C150H246N58O43S2
ANIMWY
R
3614.09
11.30
11
3
4
+6
13.62
-1.753
22.67
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
125
3.46
8
Residue Composition
number
0
A
6
R
0
N
2
D
2
C
1
E
3
Q
3
G
2
H
0
I
1
L
3
K
0
M
2
F
1
P
2
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 2 C: 2 E: 1 Q: 3 G: 3 H: 2 I: 0 L: 1 K: 3 M: 0 F: 2 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
30
C150H246N58O43S2
3614.09
11.30
+6
13.62
-1.753
Amidation
L
Cationic
Linear
Biotinylation
N[C@@H](CS)C(=O)NCC(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A2058 human melanoma cells, B16F10-Nex2 syngeneic murine melanoma, HFF and MEF cells-- A2058 and SK-MEL-28, MCF-7 and MDA-MB231, OVCAR-3 and HL-61

Assay & Model

Six-to-eight week-old, C57BL / syngeneic mice
Six-to-eight week-old, C57BL / syngeneic mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Biotin
Cytoplasm and nucleus
Higher uptake efficency
In vitro and in vivo
CBSCCCCSSCCCTTTSSSSSSSCSCCBC
Additional Detail Fields 1 fields
CBSCCCCSSCCCTTTSSSSSSSCSCCBC