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Peptide record

TPDB61400

HS-R8-PGGGAG-EK10 Cell-penetrating Peptides standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB61400
HS-R8-PGGGAG-EK10
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 38-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
Sequence
CGGGRRRRRRRRPGGGAGEKEKEKEKEKEKEKEKEKEK
Physicochemical Analysis
C183H326N72O59S1
NDQHILMFSTWYV
EK
4511.11
10.67
18
10
1
+8
36.69
-2.897
2.63
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
8
R
0
N
0
D
1
C
10
E
0
Q
7
G
0
H
0
I
0
L
10
K
0
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 8 N: 0 D: 0 C: 1 E: 10 Q: 0 G: 7 H: 0 I: 0 L: 0 K: 10 M: 0 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
38
C183H326N72O59S1
4511.11
10.67
+8
36.69
-2.897
Free
L
Linear
Free
N[C@@H](CS)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Scc-7 Cells

Assay & Model

Female nude mice bearing SCC-7 tumors
Female nude mice bearing SCC-7 tumors

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Chimeric
5-Aminolevulinic acid (ALA) conjugated AuNPs
At 4hr, the cellular uptake of HS-R8-PLGLAG-EK10-coated AuNPs was 1.48-fold higher that of MMP-2-nonsensitive HS-R8-PGGGAG-EK10-coated AuNPs
Endocytosis
In vitro and in vivo
CCSCTTTCSSSSSSSCCTTCCSSGGGGGTTTTTTTTCC
Additional Detail Fields 1 fields
CCSCTTTCSSSSSSSCCTTCCSSGGGGGTTTTTTTTCC