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Peptide record

TPDB61399

pAntp43-58-NP Cell-penetrating Peptides standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB61399
pAntp43-58-NP
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 20-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Rho-labelled N-terminal: Acetylation
Sequence
Ac-CGGGRQIKIWFQNRRMKWKK-NH2
Physicochemical Analysis
C113H182N38O24S2
ADEHLPSTYV
K
2521.05
12.16
7
0
6
+7
2.08
-1.320
39.00
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
11000
436.33
4
Residue Composition
number
0
A
3
R
1
N
0
D
1
C
0
E
2
Q
3
G
0
H
2
I
0
L
4
K
1
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 0 C: 1 E: 0 Q: 2 G: 3 H: 0 I: 2 L: 0 K: 4 M: 1 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
20
C113H182N38O24S2
2521.05
12.16
+7
2.08
-1.320
Amidation
Rho-labelled
L
Cationic
Linear
Acetylation
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Corneal Epithelial Cells (Hce-2)

Assay & Model

C57BL/6J wild-type male mice of 3 months of age
C57BL/6J wild-type male mice of 3 months of age

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Non-natural residues Linear L Cationic
Protein derived
Fluorometholone-loaded PEG-PLGA nanoparticles (NPs)
Cytoplasm
Very low internalized
In vitro and in vivo