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Peptide record

TPDB61397

G2 Cell-penetrating Peptides standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB61397
G2
Cell-penetrating Peptides
Delivery and barrier-penetrating peptides
CPPsite3.0
standard
No
A 16-aa standard natural cell-penetrating peptides peptide sequence curated from CPPsite3.0, with an available 3D structural model.
C-terminal: Amidation Chemical: Rho-labelled N-terminal: Acetylation
Sequence
Ac-CGGGMPRRRRIRRRQK-NH2
Physicochemical Analysis
C78H147N39O18S2
ANDEHLFSTWYV
R
1983.40
12.80
8
0
2
+8
6.94
-2.050
24.38
Mammalian: 1.2 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
7
R
0
N
0
D
1
C
0
E
1
Q
3
G
0
H
1
I
0
L
1
K
1
M
0
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 1 E: 0 Q: 1 G: 3 H: 0 I: 1 L: 0 K: 1 M: 1 F: 0 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
16
C78H147N39O18S2
1983.40
12.80
+8
6.94
-2.050
Amidation
Rho-labelled
L
Cationic
Linear
Acetylation
N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Human Corneal Epithelial Cells (Hce-2)

Assay & Model

C57BL/6J wild-type male mice of 3 months of age
C57BL/6J wild-type male mice of 3 months of age

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Protein derived
Fluorometholone-loaded PEG-PLGA nanoparticles (NPs)
Cytoplasm
High Internalization
In vitro and in vivo
CCSSCGGGHHHHSCCC
Additional Detail Fields 1 fields
CCSSCGGGHHHHSCCC